Eventbased integration algorithms for conductancebased integrate and fire networksEventdriven simulation strategies were proposed recently to simulate integrateandfire (IF) type neuronal models. These strategies differ from the classic "clockdriven" integration based on constant or varying time steps. In an eventdriven strategy, the neuron model must be analytically solvable, in which case one can predict the time of the next spike in any neuron. The integration is then realized by determining which is the next "event" in the network, and update all the neurons concerned. The great advantage is that such integration may be considerably faster computationally, but most important, it is also exact since the timing of the spike is calculated analytically. The drawback of such eventbased strategies is that they are possible only in simple IF models, with currentbased synaptic interactions. Unfortunately, they are not possible in more realistic conductancebased models, because the Vm activity cannot be calculated analytically in most of such models. To address this caveat, with Michelle Rudolph, we have proposed a number of extensions of the classical leaky IF neuron model involving approximations of the membrane equation with conductancebased synaptic current, which lead to simple analytic expressions for the membrane state which, therefore, can be used in the eventdriven framework [1]. We have recently proposed an extenstion to this framework, which is still analytic, but gives the full EPSP time course [5]. These conductancebased IF models (gIF models) were compared to commonly used models, such as the leaky IF model or biophysical models in which conductances are explicitly integrated. All models were compared with respect to various spiking response properties in the presence of synaptic activity, such as the spontaneous discharge statistics, the temporal precision in resolving synaptic inputs, and gain modulation under in vivolike synaptic bombardment. Being based on the passive membrane equation with fixedthreshold spike generation, the proposed gIF models are situated in between leaky IF and biophysical models, but are much closer to the latter with respect to their dynamic behavior and response characteristics, while still being nearly as computationally efficient as simple IF neuron models [1,2,5]. These new conductancebased IF models can also incorporate plasticity [2], and were also compared to other simulation strategies in terms of precision [3,4]. Extension of this approach to network simulations are presently being investigated.
[1] Rudolph, M. and Destexhe, A. Integrateandfire neurons with highconductance state dynamics for eventdriven simulation strategies. Neural Computation 18: 21462210, 2006 (see abstract) [2] Rudolph, M. and Destexhe, A. Eventbased simulation strategy for conductancebased synaptic interactions and plasticity. Neurocomputing 69: 11301133, 2006 (see abstract) [3] Brette, R., Rudolph, M., Carnevale, T., Hines, M., Beeman, D., Bower, J.M., Diesmann, M., Morrison, A., Goodman, P.H., Harris Jr., F.C., Zirpe, M., Natschlager, T., Pecevski, D., Ermentrout, B., Djurfeldt, M., Lansner, A., Rochel, O., Vieville, T., Muller, E., Davison, A.P., ElBoustani, S. and and Destexhe, A. Simulation of networks of spiking neurons: a review of tools and strategies. J. Computational Neurosci. 23: 349398, 2007 (see abstract) [4] Rudolph, M. and Destexhe, A. How much can we trust neural simulation strategies? Neurocomputing 70: 19661969, 2007 (see abstract) [5] RudolphLilith, M., Dubois, M. and Destexhe, A. Analytical integrateandfire neuron models with conductancebased dynamics and realistic postsynaptic potential time course for eventdriven simulation strategies. Neural Computation 24: 14261461, 2012 (see abstract)
Department of Integrative and Computational Neuroscience (ICN),
