NEURON DEMO FOR SIMULATING DIFFERENT CLASSES OF CORTICAL NEURONS

                          Alain Destexhe

            CNRS, UNIC (Bat-33), Avenue de la Terrasse,
                 91198 Gif-sur-Yvette, France

                     Destexhe@iaf.cnrs-gif.fr
                    http://cns.iaf.cnrs-gif.fr


This package is running with the NEURON simulation program written by Michael
Hines and available on internet at:
  http://www.neuron.yale.edu

The package contains mechanisms (.mod files) and programs (.oc files) needed to
simulate single-compartment models of cortical neurons.  Details of the
kinetics of currents are given in:

  Destexhe A and Sejnowski TJ.  Thalamocortical Assemblies.
  Oxford University Press, 2001

See also the original paper:

  Destexhe A, Contreras D and Steriade M.  Mechanisms underlying the 
  synchronizing action of corticothalamic feedback through inhibition of 
  thalamic relay cells. J. Neurophysiol. 79: 999-1016, 1998.

  Destexhe A, Contreras D and Steriade M.  LTS cells in cerebral cortex
  and their role in generating spike-and-wave oscillations.   
  Neurocomputing 38: 555-563, 2001.

(see electronic copy at  http://cns.iaf.cnrs-gif.fr)



  PROGRAMS
  ========

demo_PY_RS.oc  : regular-spiking pyramidal neuron
demo_PY_LTS.oc : bursting pyramidal neuron (LTS cell)
demo_IN_FS.oc  : fast-spiking interneuron


  MECHANISMS
  ==========

 HH2.mod		: fast sodium spikes (Na and K currents)
 IM.mod 		: slow voltage-dependent potassium current (IM)
 IT.mod 		: T-type calcium current
 cadecay.mod		: intracellular calcium dynamics


  HOW TO RUN
  ==========

To compile the demo, NEURON and INTERVIEWS must be installed and working on
the machine you are using.  Just type "nrnivmodl" to compile the mechanisms
given in the mod files.

Then, execute the main demo program by typing:

special rundemo.hoc -

Once the menu and graphics interface has appeared, select the simulation
and click on "Init and Run" to start the simulation...

For more information about how to get NEURON and how to install it, please
refer to the following sites:
  http://www.neuron.yale.edu
  http://www.neuro.duke.edu



For further information, please contact:

Alain Destexhe

CNRS, UNIC (Bat-33), 
Avenue de la Terrasse,
91198 Gif-sur-Yvette, 
France

email: Destexhe@iaf.cnrs-gif.fr
http://cns.iaf.cnrs-gif.fr