Database of Publications

Multicompartment model of a reconstructed neuron from the reticular nucleus of the thalamus of a rat. The figure shows three snapshots of activity during a burst of spikes generated by this type of cell. The distribution of membrane potential is indicated by colors: the range from -80 to +30 mV is coded from deep blue to yellow. Calcium currents located in the dendrites have a determinant influence on the properties of these cells in vitro. Dendritic calcium currents are also essential to account for the properties of these cells seen in vivo (from: Destexhe et al., In vivo, in vitro and computational analysis of dendritic calcium currents in thalamic reticular neurons, Journal of Neuroscience 16: 169-185, 1996).

Contents

All papers available in the database are published or in press and are therefore subject to copyright (see publisher for authorization to reproduce). Most papers are available in PDF or postscript format (including the figures) and for all of them, an on-line abstract can be retreived. In some cases, movie files or demos of computer simulations can be obtained.

• Overview (review articles accessible to a large audience)

• Articles

• Review Articles

• Books/Monographs

• Peer-reviewed Conference Papers

• Book Chapters

• Older Publications

• Alain Destexhe's PhD Thesis

Overview: Articles accessible to a large audience

• Intracellular and computational evidence for a dominant role of internal network activity in cortical computations.
  Alain Destexhe
  Current Opinion in Neurobiology 21: 717-725, 2011.
  (Special issue "Networks, Circuits and Computation", edited by Feldman D., Feller M. and Dayan P.)

• Neuronal computations with stochastic network states.
  Alain Destexhe and Diego Contreras
  Science 314: 85-90, 2006.

• Plasticity in single neuron and circuit computations
  Alain Destexhe and Eve Marder
  Nature 431: 789-795, 2004.

• The high-conductance state of neocortical neurons in vivo
  Alain Destexhe, Michael Rudolph and Denis Paré
  Nature Reviews Neuroscience 4: 739-751, 2003.

• High-Conductance State
  Alain Destexhe
  Scholarpedia, 2(11): 1341 (2007).

• Spike and Wave Oscillations
  Alain Destexhe
  Scholarpedia, 2(2): 1402 (2007).

• Are corticothalamic 'up' states fragments of wakefulness?
  Alain Destexhe, Stuart Hughes, Michelle Rudolph and Vincenzo Crunelli
  Trends in Neurosciences 30: 334-342, 2007.

Peer-reviewed Articles

• Analytical integrate-and-fire neuron models with conductance-based dynamics and realistic postsynaptic potential time course for event-driven simulation strategies.
  Michelle Rudolph and Alain Destexhe
  Neural Computation, in press, 2012.

• Stable learning in stochastic network states.
  Sami El Boustani, Pierre Yger, Yves Frégnac and Alain Destexhe
  Journal of Neuroscience 32: 194-214, 2012.

• Oversampling method to extract excitatory and inhibitory conductances from single-trial membrane potential recordings.
  Claude Bédard, Sébastien Béhuret, Charlotte Deleuze, Thierry Bal and Alain Destexhe
  J. Neurosci. Methods, in press, 2011.

• Intracellular and computational evidence for a dominant role of internal network activity in cortical computations
  Alain Destexhe
  Current Opinion in Neurobiology 21: 717-725, 2011.

• Topologically invariant macroscopic statistics in balanced networks of conductance-based integrate-and-fire neurons
  Pierre Yger, Sami El Boustani, Alain Destexhe and Yves Frégnac
  Journal of Computational Neuroscience, 31: 229-245, 2011.

• A generalized theory for current-source density analysis in brain tissue
  Claude Bédard and Alain Destexhe
  Physical Review E 84: 041909, 2011.

• Inhibition recruitment in prefrontal cortex during sleep spindles and gating of hippocampal inputs..
  Adrien Peyrache, Francesco Battaglia and Alain Destexhe
  Proc. Natl. Acad. Sci. USA 108: 17207-17212, 2011.

• Comparison of different neuron models to conductance-based post-stimulus time histograms obtained in cortical pyramidal cells using dynamic-clamp in vitro.
  Martin Pospischil, Zuzanna Piwkowska, Thierry Bal and Alain Destexhe
  Biological Cybernetics 105: 167-180, 2011.

• Non-homogeneous extracellular resistivity affects the current-source density profiles of Up/Down state oscillations
  Maxim Bazhenov, Peter Lonjers, Steven Skorheim, Claude Bedard and Alain Destexhe
  Phil. Trans. Roy. Soc. A 369: 3802-3819, 2011.

• A comprehensive workflow for general-purpose neural modeling with highly configurable neuromorphic hardware systems
  Daniel Brüderle et al.
  Biological Cybernetics 104: 263-296, 2011.

• Comparative power spectral analysis of simultaneous elecroencephalographic and magnetoencephalographic recordings in humans suggests non-resistive extracellular media
  Nima Dehghani*, Claude Bédard*, Sydney S. Cash, Eric Halgren and Alain Destexhe
  Journal of Computational Neuroscience 29: 405-421, 2010.
  (Special issue "Modeling Extracellular Potentials")

• Evidence for frequency-dependent extracellular impedance from the transfer function between extracellular and intracellular potentials.
  Claude Bédard, Serafim Rodrigues, Noah Roy, Diego Contreras and Alain Destexhe
  Journal of Computational Neuroscience 29: 389-403, 2010.
  (Special issue "Modeling Extracellular Potentials")

• PAX: A mixed hardware/software simulation platform for spiking neural networks.
  Renaud S, Tomas J, Lewis S, Bornat Y, Daouzli A, Rudolph M, Destexhe A and Saïghi S.
  Neural Networks 23: 905-916, 2010.

• Inhibitory "noise"
  Alain Destexhe
  Frontiers in Cellular Neuroscience 4: 9, 2010.
  Online Version: http://frontiersin.org/neuroscience/cellularneuroscience/paper/10.3389/fncel.2010.00009 .

• Can power-law scaling and neuronal avalanches arise from stochastic dynamics?
  Jonathan Touboul and Alain Destexhe
  PLoS One 5: e8982, 2010.
  Online Version: http://dx.plos.org/10.1371/journal.pone.0008982.

• Brain dynamics at multiple scales: can one reconcile the apparent low-dimensional chaos of macroscopic variables with the seemingly stochastic behavior of single neurons?
  Sami El Boustani and Alain Destexhe
  International Journal of Bifurcation and Chaos 20: 1687-1702, 2010.

• Self-sustained asynchronous irregular states and Up/Down states in thalamic, cortical and thalamocortical networks of nonlinear integrate-and-fire neurons.
  Alain Destexhe
  Journal of Computational Neuroscience 27: 493-506, 2009.

• Network-state modulation of power-law frequency-scaling in visual cortical neurons.
  Sami El Boustani, Olivier Marre, Séebastien Béhuret, Pierre Baudot, Pierre Yger, Thierry Bal, Alain Destexhe and Yves Frégnac
  PLoS Computational Biology 5: e1000519, 2009.

• Characterizing neuronal activity by describing the membrane potential as a stochastic process.
  Martin Pospischil, Zuzanna Piwkowska, Thierry Bal and Alain Destexhe
  Journal of Physiology (Paris) 103: 98-106, 2009.

• Macroscopic models of local field potentials and the apparent 1/f noise in brain activity.
  Claude Bédard and Alain Destexhe
  Biophysical Journal 96: 2589-2603, 2009.

• Prediction of spatio-temporal patterns of neural activity from pairwise correlations.
  Olivier Marre, Sami El Boustani, Yves Frégnac and Alain Destexhe
  Physical Review Letters 102: 138101, 2009.

• Extracting synaptic conductances from single membrane potential traces.
  Martin Pospischil, Zuzanna Piwkowska, Thierry Bal and Alain Destexhe
  Neuroscience 158: 545-552, 2009.

• A master equation formalism for macroscopic modeling of asynchronous irregular activity states.
  Sami El Boustani and Alain Destexhe
  Neural Computation 21: 46-100, 2009.

• State dependence of network output: Modeling and experiments.
  Farzan Nadim, Vladimir Brezina, Alain Destexhe and Christiane Linster
  Journal of Neuroscience 28: 11806-11813, 2008.

• Minimal Hodgkin-Huxley type models for different classes of cortical and thalamic neurons.
  Martin Pospischil, Maria Toledo-Rodriguez, Cyril Monier, Zuzanna Piwkowska, Thierry Bal, Yves Frégnac, Henry Markram and Alain Destexhe
  Biol. Cybernetics 99: 427-441, 2008.

• High-resolution intracellular recordings using a real-time computational model of the electrode.
  Romain Brette, Zuzanna Piwkowska, Cyril Monier, Michelle Rudolph-Lilith, Manuel Levy, Julien Fournier, Yves Frégnac, Thierry Bal and Alain Destexhe
  Neuron 59: 379-391, 2008.

• Hyperpolarization-activated graded persistent activity in the prefrontal cortex.
  Milena Winograd, Alain Destexhe and Maria V. Sanchez-Vives
  Proc. Natl. Acad. Sci. USA 105: 7298-7303, 2008.

• Characterizing synaptic conductance fluctuations in cortical neurons and their influence on spike generation.
  Zuzanna Piwkowska, Martin Pospischil, Romain Brette, Julia Sliwa, Michelle Rudolph-Lilith, Thierry Bal and Alain Destexhe
  Journal of Neuroscience Methods 169: 302-322, 2008.

• A modified cable formalism for modeling neuronal membranes at high frequencies.
  Claude Bédard and Alain Destexhe
  Biophysical Journal 94: 1133-1143, 2008.

• High-resolution intracellular recordings using a real-time computational model of the electrode.
  Romain Brette, Zuzanna Piwkowska, Michelle Rudolph-Lilith, Thierry Bal and Alain Destexhe
  arXiv preprint, http://arxiv.org/abs/0711.2075, 2007.

• Activated cortical states: experiments, analyses and models.
  Sami El Boustani, Martin Pospischil, Michelle Rudolph-Lilith and Alain Destexhe
  Journal of Physiology (Paris) 101: 99-109, 2007.

• Simulation of networks of spiking neurons: a review of tools and strategies.
  Romain Brette, Michelle Rudolph, Ted Carnevale, Michael Hines, David Beeman, James M. Bower, Markus Diesmann, Abigail Morrison, Philip H. Goodman, Frederick C. Harris, Jr., Milind Zirpe, Thomas Natschlaeger, Dejan Pecevski, Bard Ermentrout, Mikael Djurfeldt, Anders Lansner, Olivier Rochel, Thierry Vieville, Eilif Muller, Andrew P. Davison, Sami El Boustani and Alain Destexhe
  Journal of Computational Neuroscience 23: 349-398, 2007.

• Inhibition determines membrane potential dynamics and controls action potential generation in awake and sleeping cat cortex.
  Michelle Rudolph, Martin Pospischil, Igor Timofeev and Alain Destexhe
  Journal of Neuroscience 27: 5280-5290, 2007.

• Are corticothalamic 'up' states fragments of wakefulness?
  Alain Destexhe, Stuart Hughes, Michelle Rudolph and Vincenzo Crunelli
  Trends in Neurosciences 30: 334-342, 2007.

• Kinetic models of spike-timing dependent plasticity and their functional consequences in detecting correlations.
  Quan Zou and Alain Destexhe
  Biological Cybernetics 97: 81-97, 2007.

• Calculating event-triggered average synaptic conductances from the membrane potential.
  Martin Pospischil, Zuzanna Piwkowska, Michelle Rudolph, Thierry Bal and Alain Destexhe
  Journal of Neurophysiology 97: 2544-2552, 2007.

• Analog-digital simulations of full conductance-based networks of spiking neurons with spike timing dependent plasticity.
  Quan Zou, Yannick Bornat, Sylvain Saïghi, Jean Tomas, Sylvie Renaud and Alain Destexhe
  Network 17: 211-233, 2006.

• On the use of analytic expressions for the voltage distribution to analyze intracellular recordings.
  Michelle Rudolph and Alain Destexhe
  Neural Computation 18: 2917-2922, 2006.

• Neuronal computations with stochastic network states.
  Alain Destexhe and Diego Contreras
  Science 314: 85-90, 2006.

• Does the 1/f frequency-scaling of brain signals reflect self-organized critical states?
  Claude Bédard, Helmut Kroger and Alain Destexhe
  Physical Review Letters 97: 118102, 2006.

• Integrate-and-fire neurons with high-conductance state dynamics for event-driven simulation strategies.
  Michelle Rudolph and Alain Destexhe
  Neural Computation 18: 2146-2210, 2006.

• A multichannel shot noise approach to describe synaptic background activity in neurons.
  Michelle Rudolph and Alain Destexhe
  European Physical Journal B 52: 125-132, 2006.

• Model of low-pass filtering of local field potentials in brain tissue
  Claude Bédard, Helmut Kroger and Alain Destexhe
  Physical Review E 73: 051911, 2006.

• Biophysical and phenomenological models of multiple spike interactions in spike-timing dependent plasticity.
  Mathilde Badoual, Quan Zou, Andrew P. Davison, Michael Rudolph, Thierry Bal, Yves Frégnac and Alain Destexhe
  International Journal of Neural Systems 16: 79-97, 2006.

• Synaptic background activity controls spike transfer from thalamus to cortex.
  Jakob Wolfart, Damien Debay, Gwen Le Masson, Alain Destexhe and Thierry Bal
  Nature Neuroscience 8: 1760-1767, 2005.

• Characterization of synaptic conductances and integrative properties during electrically-induced EEG-activated states in neocortical neurons in vivo.
  Michael Rudolph, Joe-Guillaume Pelletier, Denis Paré and Alain Destexhe
  Journal of Neurophysiology 94: 2805-2821, 2005.

• An extended analytic expression for the membrane potential distribution of conductance-based synaptic noise
  Michael Rudolph and Alain Destexhe
  Neural Computation 17: 2301-2315, 2005.

• Inferring network activity from synaptic noise
  Michael Rudolph and Alain Destexhe
  Journal of Physiology (Paris) 98: 452-466, 2004.

• Plasticity in single neuron and circuit computations
  Alain Destexhe and Eve Marder
  Nature 431: 789-795, 2004.

• Extracting information from the power spectrum of synaptic noise
  Alain Destexhe and Michael Rudolph
  Journal of Computational Neuroscience 17: 327-345, 2004.

• A method to estimate synaptic conductances from membrane potential fluctuations
  Michael Rudolph, Zuzanna Piwkowska, Mathilde Badoual, Thierry Bal and Alain Destexhe
  Journal of Neurophysiology 91: 2884-2896, 2004.

• Modeling extracellular field potentials and the frequency-filtering properties of extracellular space
  Claude Bédard, Helmut Kroger and Alain Destexhe
  Biophysical Journal 86: 1829-1842, 2004.

• The high-conductance state of neocortical neurons in vivo
  Alain Destexhe, Michael Rudolph and Denis Paré
  Nature Reviews Neuroscience 4: 739-751, 2003.

• Interactions between membrane conductances underlying thalamocortical slow-wave oscillations
  Alain Destexhe and Terrence Sejnowski
  Physiological Reviews 83: 1401-1453, 2003.

• Synaptic background noise controls the input/output characteristics of single cells in an in vitro model of in-vivo activity
  Jean-Marc Fellous, Michael Rudolph, Alain Destexhe and Terrence J. Sejnowski
  Neuroscience 122: 811-829, 2003.

• Characterization of subthreshold voltage fluctuations in neuronal membranes
  Michael Rudolph and Alain Destexhe
  Neural Computation 15: 2577-2618, 2003.

• The discharge variability of neocortical neurons during high-conductance states
  Michael Rudolph and Alain Destexhe
  Neuroscience 119: 855-873, 2003.

• Tuning neocortical pyramidal neurons between integrators and coincidence detectors
  Michael Rudolph and Alain Destexhe
  Journal of Computational Neuroscience 14: 239-251, 2003.

• A fast conducting, stochastic integrative mode for neocortical neurons in vivo
  Michael Rudolph and Alain Destexhe
  Journal of Neuroscience 23: 2466-2476, 2003.

• Variability of quantal synaptic currents in thalamocortical neurons
  Mike Neubig, Alain Destexhe and Terrence J. Sejnowski
  Thalamus and Related Systems 2: 153-168, 2003.

• The initiation of bursts in thalamic neurons and the cortical control of thalamic sensitivity
  Alain Destexhe and Terrence J. Sejnowski
  Phil. Trans. Roy. Soc. Lond. Series B. 357: 1649-1657, 2002.

• Fluctuating synaptic conductances recreate in-vivo-like activity in neocortical neurons
  Alain Destexhe, Michael Rudolph, Jean-Marc Fellous and Terrence J. Sejnowski
  Neuroscience 107: 13-24, 2001.

• Do neocortical pyramidal neurons display stochastic resonance?
  Michael Rudolph and Alain Destexhe
  Journal of Computational Neuroscience 11: 19-42, 2001.

• Correlation detection and resonance in neural systems with distributed noise sources
  Michael Rudolph and Alain Destexhe
  Physical Review Letters 86: 3662-3665, 2001.

• Dendritic organization in thalamocortical neurons and state-dependent functions of inhibitory synaptic inputs
  Mike Neubig and Alain Destexhe
  Thalamus and Related Systems 1: 39-52, 2001.

• Modeling corticothalamic feedback and the gating of the thalamus by the cerebral cortex
  Alain Destexhe
  Journal of Physiology (Paris) 94: 391-410, 2000.

• Cortical feedback controls the frequency and synchrony of oscillations in the visual thalamus
  Thierry Bal, Damien Debay and Alain Destexhe
  Journal of Neuroscience 20: 7478-7488, 2000.

• Nonlinear thermodynamic models of voltage-dependent currents
  Alain Destexhe and John R. Huguenard
  Journal of Computational Neuroscience 9: 259-270, 2000.

• Synaptic background activity enhances the responsiveness of neocortical pyramidal neurons
  Nicolas Hô and Alain Destexhe
  Journal of Neurophysiology 84: 1488-1496, 2000.

• Impact of network activity on the integrative properties of neocortical pyramidal neurons in vivo
  Alain Destexhe and Denis Paré
  Journal of Neurophysiology 81: 1531-1547, 1999

• Spatiotemporal analysis of local field potentials and unit discharges in cat cerebral cortex during natural wake and sleep states
  Alain Destexhe, Diego Contreras and Mircea Steriade
  Journal of Neuroscience 19: 4595-4608, 1999

• Cortically-induced coherence of a thalamic-generated oscillation
  Alain Destexhe, Diego Contreras and Mircea Steriade
  Neuroscience 92: 427-443, 1999

• Dual intracellular recordings and computational models of slow inhibitory postsynaptic potentials in rat neocortical and hippocampal slices
  Alex M. Thomson and Alain Destexhe
  Neuroscience 92: 1193-1215, 1999

• Can GABA_A conductances explain the fast oscillation frequency of absence seizures in rodents?
  Alain Destexhe
  European Journal of Neuroscience 11: 2175-2181, 1999

• Spike-and-wave oscillations based on the properties of GABA_B receptors
  Alain Destexhe
  Journal of Neuroscience 18: 9099-9111, 1998

• Dendritic low-threshold calcium currents in thalamic relay cells
  Alain Destexhe, Mike Neubig, Daniel Ulrich and John R. Huguenard
  Journal of Neuroscience 18: 3574-3588, 1998

• Impact of spontaneous synaptic activity on the resting properties of cat neocortical neurons in vivo
  Denis Paré, Eric Shink, Hélène Gaudreau, Alain Destexhe and Erik Lang
  Journal of Neurophysiology 79: 1450-1460, 1998

• Inhibitory control of somatic and dendritic sodium spikes in neocortical pyramidal neurons in vivo: an intracellular and computational study
  Denis Paré, Erik Lang and Alain Destexhe
  Neuroscience 84: 377-402, 1998

• Mechanisms underlying the synchronizing action of corticothalamic feedback through inhibition of thalamic relay cells
  Alain Destexhe, Diego Contreras and Mircea Steriade
  Journal of Neurophysiology 79: 999-1016, 1998

• Spatiotemporal Patterns of Spindle Oscillations in Cortex and Thalamus
  Diego Contreras, Alain Destexhe, Terrence J. Sejnowski and Mircea Steriade
  Journal of Neuroscience 17: 1179-1196, 1997

• Spindle oscillations during cortical spreading depression in naturally sleeping cats
  Diego Contreras, Alain Destexhe and Mircea Steriade
  Neuroscience 77: 933-936, 1997

• Intracellular and computational characterization of the intracortical inhibitory control of synchronized thalamic inputs in vivo
  Diego Contreras, Alain Destexhe and Mircea Steriade
  Journal of Neurophysiology 77: 335-350, 1997

• Dynamic interactions determine partial thalamic quiescence in a computer network model of spike-and-wave seizures
  William W. Lytton, Diego Contreras, Alain Destexhe and Mircea Steriade
  Journal of Neurophysiology 77: 1679-1696, 1997

• Conductance-based integrate and fire models
  Alain Destexhe
  Neural Computation 9: 503-514, 1997

• Control of Spatiotemporal Coherence of a Thalamic Oscillation by Corticothalamic Feedback
  Diego Contreras, Alain Destexhe, Terrence J. Sejnowski and Mircea Steriade
  Science 274: 771-774, 1996

• Ionic mechanisms underlying synchronized oscillations and propagating waves in a model of ferret thalamic slices
  Alain Destexhe, Thierry Bal, David A. McCormick and Terrence J. Sejnowski
  Journal of Neurophysiology 76: 2049-2070, 1996

• In vivo, in vitro and computational analysis of dendritic calcium currents in thalamic reticular neurons
  Alain Destexhe, Diego Contreras, Mircea Steriade, Terrence J. Sejnowski and John R. Huguenard
  Journal of Neuroscience 16: 169-185, 1996

• Control of slow oscillations in the thalamocortical neuron: a computer model
  William W. Lytton, Alain Destexhe and Terrence J. Sejnowski
  Neuroscience 70: 673-684, 1996

• G-protein activation kinetics and spill-over of GABA may account for differences between inhibitory responses in the hippocampus and thalamus
  Alain Destexhe and Terrence J. Sejnowski
  Proc. Natl. Acad. Sci. USA 92: 9515-9519, 1995

• Modeling the control of reticular thalamic oscillations by neuromodulators
  Alain Destexhe, Diego Contreras, Terrence J. Sejnowski and Mircea Steriade
  NeuroReport 5: 2217-2220, 1994

• A model of spindle rhythmicity in the isolated thalamic reticular nucleus
  Alain Destexhe, Diego Contreras, Terrence J. Sejnowski and Mircea Steriade
  Journal of Neurophysiology 72: 803-818, 1994

• Synthesis of models for excitable membranes, synaptic transmission and neuromodulation using a common kinetic formalism
  Alain Destexhe, Zachary F. Mainen and Terrence J. Sejnowski
  Journal of Computational Neuroscience 1: 195-230, 1994

• An efficient method for computing synaptic conductances based on a kinetic model of receptor binding
  Alain Destexhe, Zachary F. Mainen and Terrence J. Sejnowski
  Neural Computation 6: 14-18, 1994

• Oscillations, complex spatiotemporal behavior and information transport in networks of excitatory and inhibitory neurons
  Alain Destexhe
  Physical Review E 50: 1594-1606, 1994

• Stability of periodic oscillations in a network of neurons with time delay
  Alain Destexhe
  Physics Letters A 187: 309-316, 1994

• A model for 8-10 Hz spindling in interconnected thalamic relay and reticularis neurons
  Alain Destexhe, David A. McCormick and Terrence J. Sejnowski
  Biophysical Journal 65: 2473-2477, 1993

• Ionic mechanisms for intrinsic slow oscillations in thalamic relay neurons
  Alain Destexhe, Agnessa Babloyantz and Terrence J. Sejnowski
  Biophysical Journal 65: 1538-1552, 1993

• A Model of the Inward Current Ih and its Possible Role in Thalamocortical Oscillations
  Alain Destexhe and Agnessa Babloyantz
  NeuroReport 4: 223-226, 1993

• Bursting oscillations from a homoclinic tangency in a time delay system
  Alain Destexhe and Pierre Gaspard
  Physics Letters A 173: 386-391, 1993

Review Articles

• Intracellular and computational evidence for a dominant role of internal network activity in cortical computations.
  Alain Destexhe
  Current Opinion in Neurobiology 21: 717-725, 2011.
  (Special issue "Networks, Circuits and Computation", edited by Feldman D., Feller M. and Dayan P.)

• Modeling local field potentials and their interaction with the extracellular medium.
  Claude Bedard and Alain Destexhe

  In: Handbook of Neural Activity Measurement, Edited by Brette R and Destexhe A, Cambridge University Press, Cambridge, UK, in press (2011).

• Inhibitory "noise"
  Alain Destexhe
  Frontiers in Neuroscience 4: 9 (2010).

• Synaptic "noise": Experiments, computational consequences and methods to analyze experimental data.
  Alain Destexhe and Michelle Rudolph-Lilith
  In: Stochastic Methods in Neuroscience, Edited by Laing C and Lord GJ, Oxford University Press, Oxford UK, pp. 242-271 (2010).

• Sleep oscillations.
  Alain Destexhe
  In: Encyclopedia of Neuroscience, Edited by Squire LR, Academic Press, Oxford. Vol. 8, pp. 1037-1044 (2009).

• Sleep and sleep States: Thalamic regulation.
  Alain Destexhe and Terrence J. Sejnowski
  In: Encyclopedia of Neuroscience, Edited by Squire LR, Academic Press, Oxford. Vol. 8, pp. 973-976 (2009).

• Minimal Hodgkin-Huxley type models for different classes of cortical and thalamic neurons.
  Martin Pospischil, Maria Toledo-Rodriguez, Cyril Monier, Zuzanna Piwkowska, Thierry Bal, Yves Frégnac, Henry Markram and Alain Destexhe
  Biol. Cybernetics
  99: 427-441, 2008.

• Characterizing synaptic conductance fluctuations in cortical neurons and their influence on spike generation.
  Zuzanna Piwkowska, Martin Pospischil, Romain Brette, Julia Sliwa, Michelle Rudolph-Lilith, Thierry Bal and Alain Destexhe
  Journal of Neuroscience Methods 169: 302-322, 2008.

• Corticothalamic feedback: a key to explain absence seizures
  Alain Destexhe
  In: Computational Neuroscience in Epilepsy, Edited by Soltesz, I. and Staley, K., Elsevier, Amsterdam, pp. 184-214 (2008).

• Spike and Wave Oscillations
  Alain Destexhe
  Scholarpedia, 2(2): 1402 (2007).

• High-Conductance State
  Alain Destexhe
  Scholarpedia, 2(11): 1341 (2007).

• Simulation of networks of spiking neurons: a review of tools and strategies.
  Romain Brette, Michelle Rudolph, Ted Carnevale, Michael Hines, David Beeman, James M. Bower, Markus Diesmann, Abigail Morrison, Philip H. Goodman, Frederick C. Harris, Jr., Milind Zirpe, Thomas Natschlaeger, Dejan Pecevski, Bard Ermentrout, Mikael Djurfeldt, Anders Lansner, Olivier Rochel, Thierry Vieville, Eilif Muller, Andrew P. Davison, Sami El Boustani and Alain Destexhe
  Journal of Computational Neuroscience 23: 349-398, 2007.

• Are corticothalamic 'up' states fragments of wakefulness?
  Alain Destexhe, Stuart Hughes, Michelle Rudolph and Vincenzo Crunelli
  Trends in Neurosciences 30: 334-342, 2007.

• Complexity in neuronal networks.
  Yves Frégnac, Michelle Rudolph, Andrew P. Davison and Alain Destexhe
  In: Biological Networks, Edited by Kepes, F. World Scientific, Singapore, pp. 291-340 (2007).

• Neuronal computations with stochastic network states.
  Alain Destexhe and Diego Contreras
  Science 314: 85-90, 2006.

• Plasticity in single neuron and circuit computations
  Alain Destexhe and Eve Marder
  Nature 431: 789-795, 2004.

• Inferring network activity from synaptic noise
  Michael Rudolph and Alain Destexhe
  Journal of Physiology (Paris) 98: 452-466, 2004.

• The high-conductance state of neocortical neurons in vivo
  Alain Destexhe, Michael Rudolph and Denis Paré
  Nature Reviews Neuroscience 4: 739-751, 2003.

• Interactions between membrane conductances underlying thalamocortical slow-wave oscillations
  Alain Destexhe and Terrence Sejnowski
  Physiological Reviews 83: 1401-1453, 2003.

• Why do we sleep?
  Terrence J. Sejnowski and Alain Destexhe
  Brain Research 886: 208-223, 2000.

• Kinetic models of membrane excitability and synaptic interactions
  Alain Destexhe
  In: Computational Modeling of Genetic and Biochemical Networks, Edited by J.M. Bower and H. Bolouri, MIT Press, Cambridge, 2000, pp. 225-262.

• Thalamic and thalamocortical mechanisms underlying 3 Hz spike-and-wave discharges
  Alain Destexhe, David A. McCormick and Terrence J. Sejnowski
  Progress in Brain Research 121: 289-307, 1999.

• Kinetic models of synaptic transmission
  Alain Destexhe, Zachary F. Mainen and Terrence J. Sejnowski
  In: Methods in Neuronal Modeling, 2nd Edition, Edited by Koch, C. and Segev, I., MIT Press, Cambridge, MA, 1998, pp. 1-25.

• Synchronized oscillations in thalamic networks: insights from modeling studies
  Alain Destexhe and Terrence J. Sejnowski
  In: Thalamus, Edited by Steriade, M., Jones, E.G. and McCormick, D.A., Elsevier, New York, 1997, pp. 331-371.

Books and Monographs

• Neuronal Noise
  Alain Destexhe and Michelle Rudolph
  Springer (in preparation; expected date for publication: 2010)

• Dynamic Clamp: From Principles to Applications
  Alain Destexhe and Thierry Bal (Editors)
  Springer, 2009 (ISBN 978-0-387-89278-8).
  (see also the The Springer Web page of the book)

• Thalamocortical Assemblies
  Alain Destexhe and Terrence J. Sejnowski
  Oxford University Press, 2001 (ISBN 0-19-852425-0).
  (see also the OUP webpage of the book)

Peer-reviewed Conference Papers

• A nonparametric electrode model for intracellular recording.
  Romain Brette, Zuzanna Piwkowska, Michelle Rudolph, Thierry Bal and Alain Destexhe
  Neurocomputing 70: 1597-1601, 2007.

• Inhibitory conductance dynamics in cortical neurons during activated states
  Martin Pospischil, Zuzanna Piwkowska, Michelle Rudolph, Thierry Bal and Alain Destexhe
  Neurocomputing 70: 1602-1604, 2007.

• How much can we trust neural simulation strategies?
  Michelle Rudolph and Alain Destexhe
  Neurocomputing 70: 1966-1969, 2007.

• Event-based simulation strategy for conductance-based synaptic interactions and plasticity.
  Michelle Rudolph and Alain Destexhe
  Neurocomputing 69: 1130-1133, 2006.

• Real-time simulations of networks of Hodgkin-Huxley neurons using analog circuits.
  Quan Zou, Yannick Bornat, Jean Tomas, Sylvie Renaud and Alain Destexhe
  Neurocomputing 69: 1137-1140, 2006.

• Extracting information from the power spectrum of voltage noise.
  Alain Destexhe and Michael Rudolph
  Neurocomputing 65: 901-906, 2005.

• Multi-channel shot noise and characterization of cortical network activity.
  Michael Rudolph and Alain Destexhe
  Neurocomputing 65: 641-646, 2005.

• Reconstructing synaptic background activity from conductance measurements in vivo.
  Quan Zou, Michael Rudolph, Noah Roy, Mavi Sanchez-Vives, Diego Contreras and Alain Destexhe
  Neurocomputing 65: 673-678, 2005.

• Recreating active states in vitro with a dynamic clamp protocol.
  Zuzanna Piwkowska, Michael Rudolph, Mathilde Badoual, Alain Destexhe and Thierry Bal
  Neurocomputing 65: 55-60, 2005.

• High discharge variability in neurons driven by current noise.
  Mathilde Badoual, Michael Rudolph, Zuzanna Piwkowska, Alain Destexhe and Thierry Bal
  Neurocomputing 65: 493-498, 2005.

• Estimation of synaptic conductances and their variances from intracellular recordings of neocortical neurons in vivo
  Michael Rudolph, Joe-Guillaume Pelletier, Denis Paré and Alain Destexhe
  Neurocomputing 58: 387-392, 2004.

• A novel method for characterizing synaptic noise in cortical neurons
  Alain Destexhe, Mathilde Badoual, Zuzanna Piwkowska, Thierry Bal and Michael Rudolph
  Neurocomputing 58: 191-196, 2004.

• Simulating cortical network activity states constrained by intracellular recordings
  Fabian Alvarez and Alain Destexhe
  Neurocomputing 58: 285-290, 2004.

• Hardware computation of conductance-based neuron models
  Ludovic Alvado, Jean Tomas, Sylvain Saïighi, Sylvie Renaud, Thierry Bal, Alain Destexhe and Gwendael LeMasson
  Neurocomputing 58: 109-115, 2004.

• Gain modulation and frequency locking under conductance noise
  Michael Rudolph and Alain Destexhe
  Neurocomputing 52: 907-912, 2003.

• Location independence and fast conduction of synaptic inputs in neocortical neurons in vivo
  Alain Destexhe and Michael Rudolph
  Neurocomputing 52: 233-238, 2003.

• Novel dynamics of dendritic integration in the high conductance state of cortical neurons
  Michael Rudolph and Alain Destexhe
  Neurocomputing 44: 141-146, 2002.

• Point-conductance models of cortical neurons with high discharge variability
  Michael Rudolph and Alain Destexhe
  Neurocomputing 44: 147-152, 2002.

• LTS cells in cerebral cortex and their role in generating spike-and-wave oscillations
  Alain Destexhe, Diego Contreras and Mircea Steriade
  Neurocomputing 38: 555-563, 2001.

• Corticothalamic feedback can induce hypersynchronous low-frequency rhythms in the physiologically intact thalamus
  Damien Debay, Alain Destexhe and Thierry Bal
  Neurocomputing 38: 529-538, 2001.

• Synaptic background activity affects the dynamics of dendritic integration in model neocortical pyramidal neurons
  Michael Rudolph, Nicolas Hô and Alain Destexhe
  Neurocomputing 38: 327-333, 2001.

• Simplified models of neocortical pyramidal cells preserving somatodendritic voltage attenuation
  Alain Destexhe
  Neurocomputing 38: 167-173, 2001.

• A combined computational and intracellular study of correlated synaptic bombardment in neocortical pyramidal neurons in vivo
  Alain Destexhe and Denis Paré
  Neurocomputing 32-33: 113-119, 2000.

• Consequences of correlated synaptic bombardment on the responsiveness of neocortical pyramidal neurons
  Nicolas Hô, Helmut Kroger and Alain Destexhe
  Neurocomputing 32-33: 155-160, 2000.

• Are the conductances of inhibitory synapses on thalamic relay neurons inhomogeneous? Are synapses from individual afferents clustered?
  Mike Neubig and Alain Destexhe
  Neurocomputing 32-33: 213-218, 2000.

• Low-threshold calcium I-V curve geometry is alterable through the distribution of T-channels in thalamic relay neurons
  Mike Neubig and Alain Destexhe
  Neurocomputing 26-27: 215-221, 1999

• Somato-dendritic interactions underlying action potential generation in neocortical pyramidal cells in vivo
  Alain Destexhe, Erik Lang and Denis Paré
  In: Computational Neuroscience. Trends in Research (edited by J. Bower), Plenum Press, New York, pp. 167-172, 1998

• Dendritic calcium currents in thalamic relay cells
  Mike Neubig, Ulrich, John Huguenard and Alain Destexhe
  In: Computational Neuroscience. Trends in Research (edited by J. Bower), Plenum Press, New York, pp. 233-238, 1998

• Computational models constrained by voltage-clamp data for investigating dendritic currents
  Alain Destexhe, Diego Contreras, Mircea Steriade, Terrence J. Sejnowski and John R. Huguenard
  In: Computational Neuroscience, Edited by Bower, J., Academic Press, New York, 1996, pp. 53-58.

• Fast kinetic models for simulating AMPA, NMDA, GABA_A and GABA_B receptors
  Alain Destexhe, Zachary F. Mainen and Terrence J. Sejnowski
  In: The Neurobiology of Computation, Edited by Bower, J., Kluwer Academic Press, Norwell MA, 1995, pp. 9-14.

Book Chapters

• Modeling local field potentials and their interaction with the extracellular medium.
  Claude Bedard and Alain Destexhe

  In: Handbook of Neural Activity Measurement, Edited by Brette R and Destexhe A, Cambridge University Press, Cambridge, UK, in press (2011).

• Synaptic "noise": Experiments, computational consequences and methods to analyze experimental data.
  Alain Destexhe and Michelle Rudolph-Lilith
  In: Stochastic Methods in Neuroscience, Edited by Laing C and Lord GJ, Oxford University Press, Oxford UK, pp. 242-271 (2010).

• Corticothalamic feedback: a key to explain absence seizures
  Alain Destexhe
  In: Computational Neuroscience in Epilepsy, Edited by Soltesz, I. and Staley, K., Elsevier, Amsterdam, pp. 184-214 (2008).

• Complexity in neuronal networks.
  Yves Frégnac, Michelle Rudolph, Andrew P. Davison and Alain Destexhe
  In: Biological Networks, Edited by Kepes, F. World Scientific, Singapore, pp. 291-340 (2007).

• Sleep oscillations
  Alain Destexhe and Terrence J. Sejnowski
  In: The Handbook of Brain Theory and Neural Networks (2nd edition), Edited by M.A. Arbib, MIT Press, 2002, pp. 1049-1053.

• Synaptic interactions
  Alain Destexhe, Zachary F. Mainen and Terrence J. Sejnowski
  In: The Handbook of Brain Theory and Neural Networks (2nd edition), Edited by M.A. Arbib, MIT Press, 2002, pp. 1126-1130.

• Which formalism to use for modeling voltage-dependent conductances?
  Alain Destexhe and John R. Huguenard
  In: Computational Neuroscience: Realistic Modeling for Experimentalists, Edited by E. DeSchutter, CRC Press, Boca Raton FL, 2000, pp. 129-157.

• Synaptic currents, neuromodulation and kinetic models
  Alain Destexhe, Zachary F. Mainen and Terrence J. Sejnowski
  In: The Handbook of Brain Theory and Neural Networks, Edited by M.A. Arbib, MIT Press, 1995, pp. 956-959.

Abstracts

Older Publications

Demos of Simulations

Alain Destexhe's PhD Thesis

For more information, please contact:

Unité de Neurosciences, Information & Complexité (UNIC)
CNRS
UPR-3293, Bat 33,
1 Avenue de la Terrasse,
91198 Gif-sur-Yvette, France.