Alain Destexhe and Terrence J. Sejnowski
In: The Handbook of Brain Theory and Neural Networks (2nd
edition), Edited by M.A. Arbib, MIT Press, 2002, pp. 1049-1053.
Computational models of neurons using conductance-based mechanisms integrate
electrophysiological data from both in vitro and in vivo preparations. This
approach reconciles apparently conflicting experimental data and has generated
experimental predictions (some of which have been tested and verified). In
particular, a coherent framework has been proposed to explain the genesis of
sleep spindles and pathological behavior such as absence seizures based on
data from the level of ion channels to large-scale networks interactions.
These data have led to a program for examining how sleep oscillations could
take part in memory consolidation (see details in Destexhe and Sejnowski,
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