Sleep oscillations

Alain Destexhe and Terrence J. Sejnowski

In: The Handbook of Brain Theory and Neural Networks (2nd edition), Edited by M.A. Arbib, MIT Press, 2002, pp. 1049-1053.

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Computational models of neurons using conductance-based mechanisms integrate electrophysiological data from both in vitro and in vivo preparations. This approach reconciles apparently conflicting experimental data and has generated experimental predictions (some of which have been tested and verified). In particular, a coherent framework has been proposed to explain the genesis of sleep spindles and pathological behavior such as absence seizures based on data from the level of ion channels to large-scale networks interactions. These data have led to a program for examining how sleep oscillations could take part in memory consolidation (see details in Destexhe and Sejnowski, 2001).
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