Consequences of correlated synaptic bombardment on the responsiveness of
neocortical pyramidal neurons.
Nicolas Hô, Helmut Kroger and Alain Destexhe
Neurocomputing 32-33: 155-160, 2000.
Model neocortical pyramidal neurons were investigated to evaluate the impact
of correlated synaptic bombardment on cellular responsiveness. The responses
to simulated glutamatergic (AMPA-mediated) excitatory inputs were analyzed by
comparing correlated and uncorrelated background activity. Pyramidal cells
behaved stochastically, consistent with the high variability of responses
typically observed in vivo. Interestingly, the responsiveness was enhanced in
the presence of correlated background activity, allowing the neuron to respond
to inputs that would normally be subthreshold. We suggest that during active
states, neocortical neurons should be described by stochastic equations which
may better reflect their behavior, compared to a deterministic description.
See also the following related articles:
Hô N and Destexhe A. Synaptic background
activity enhances the responsiveness of neocortical pyramidal neurons.
Journal of Neurophysiology 84: 1488-1496, 2000.
Destexhe A and Paré D, Impact of network
activity on the integrative properties of neocortical pyramidal neurons in
vivo. Journal of Neurophysiology 81: 1531-1547, 1999.
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