Dendritic calcium currents in thalamic relay cells
Mike Neubig, Ulrich, John Huguenard and Alain Destexhe
In: Computational Neuroscience. Trends in Research (edited by J.
Bower), Plenum Press, New York, pp 233-238, 1998.
Techniques of in vitro whole-cell recording and compartmental modeling were
combined to investigate dendritic structure and calcium currents in individual
thalamocortical neurons. Voltage-clamp recordings of I_T obtained in intact
and dissociated ventrobasal neurons were used to constrain I_T conductances
and passive parameters incorporated in morphorealistic models. High dendritic
I_T densities were found necessary to establish congruent model behavior.
Several methodologies based on axial resistance conservation were developed to
algorithmically reduce thalamocortical morphology into a behaviorally
congruent low-order compartmental model. This type of simplified model is
suitable for investigating the functional role played by distal T-current
localization at the network level in sleep oscillations and epilepsy.
See also the original article: Destexhe A, Neubig M,
Ulrich D and Huguenard JR. Dendritic low-threshold calcium currents in thalamic
relay cells. J. Neurosci. 18: 3574-3588, 1998
return to main page