High discharge variability in neurons driven by current noise
Mathilde Badoual, Michael Rudolph, Zuzanna Piwkowska, Alain Destexhe and
Neurocomputing 65: 493-498, 2005.
Cortical neurons in vivo show a highly irregular spontaneous discharge
activity, characterized by a gamma statistics and coefficient of variation around
unity. Modelling studies showed that this irregularity is a consequence of the
high-conductance state caused by the ongoing activityin the cortical network.
Here, we investigate to which extent this high discharge variability can be
reproduced in vitro using current noise injection. In agreement with
numerical studies, we found that equalizing the time constant of the noisy input
with the membrane time constant may lead to an irregular discharge activity
which, however, departs from a gamma statistics.
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