Recreating active states in vitro with a dynamic clamp protocol
Zuzanna Piwkowska, Michael Rudolph, Mathilde Badoual, Alain Destexhe and
Neurocomputing 65: 55-60, 2005.
In neocortical neurons, network activity is responsible for intense synaptic
inputs, which maintain the membrane in a high-conductance state. Here, we
propose a method for recreating specific high-conductance states intracellularly.
This method makes use of the estimation of the mean and variance of excitatory
and inhibitory conductances based on intracellular recordings, and of the
injection of appropriate stochastic conductances in in vitro slice
preparations using a dynamic-clamp protocol. The approach could be used to
evaluate the modulation of neuronal responses by specific network states.
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