A novel method for characterizing synaptic noise in cortical neurons
Alain Destexhe, Mathilde Badoual, Zuzanna Piwkowska, Thierry Bal and Michael
Neurocomputing 58: 191-196, 2004.
Cortical neurons in vivo are subject to intense synaptic noise that has a
significant impact on various electrophysiological properties. Here we
characterize the subthreshold activity of cortical neurons using an explicit
solution of the passive membrane equation subject to independent inhibitory and
excitatory conductance noise sources described by stochastic random-walk
processes. The analytic expression for the membrane potential distribution can be
used to estimate the average and variance of synaptic conductances from
intracellular recordings obtained under current clamp. We demonstrate the
application of this method to neuronal models of various complexity as well as to
in vitro intracellular recordings.
return to main page