Location independence and fast conduction of synaptic
inputs in neocortical neurons in vivo.
Alain Destexhe and Michael Rudolph
Neurocomputing 52: 233-238, 2003.
Neocortical neurons in vivo operate in a high-conductance
state characterized by an intense intracellular fluctuating
activity. Here we investigate how these conditions impact
on the dendritic integration of synaptic inputs by using
biophysical models of morphologically-reconstructed neocortical
pyramidal neurons. We find that the combined effect of high
conductance and fluctuating activity due to the synaptic background
activity may set pyramidal neurons into an integrative mode which
is determined by the intensity of network activity, which is
fast-conducting and in which the impact of inputs is roughly
return to main page