Biophysical and phenomenological models of multiple spike interactions
in spike-timing dependent plasticity
Mathilde Badoual, Quan Zou, Andrew P. Davison, Michael Rudolph, Thierry Bal,
Yves Frégnac and Alain Destexhe
International Journal of Neural Systems 16: 79-97, 2006.
Abstract
Spike-timing dependent plasticity (STDP) is a form of associative
synaptic modification which depends on the respective timing of pre- and
post-synaptic spikes. The biophysical mechanisms underlying this form of
plasticity are currently not known. We present here a biophysical model which
captures the characteristics of STDP, such as its frequency dependency, and the
effects of spike pair or spike triplet interactions. We also make links with
other well-known plasticity rules. A simplified phenomenological model is also
derived, which should be useful for fast numerical simulation and analytical
investigation of the impact of STDP at the network level.
(see also the
ModelDB database at Yale University)
return to
publication list
return to main page