Electrophysiological monitoring of inhibition in mammalian
species, from rodents to humans.
Adrien Peyrache and Alain Destexhe
Neurobiology of Disease 130: 104500, 2019.
GABAergic interneurons constitute a highly diverse family of
neurons that play a critical role in cortical functions. Due to
their prominent role in cortical network dynamics, genetic,
developmental, or other dysfunctions in GABAergic neurons have been
linked to neurological disorders such as epilepsy. Thus it is
crucial to investigate the interaction of these various neurons and
to develop methods to specifically and directly monitor inhibitory
activity in vivo. While research in small mammals has benefited
from a wealth of recent technological development, bridging the gap
to large mammals and humans remains a challenge. This is of
particular interest since single neuron monitoring with
intracranial electrodes in epileptic patients is developing
quickly, opening new avenues for understanding the role of
different cell types in epilepsy. Here we review currently
available techniques that monitor inhibitory activity in the brain
and the respective validations in rodents. Finally, we discuss the
future developments of these techniques and how knowledge from
animal research can be translated to the study of neuronal circuit
dynamics in the human brain.
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