Sleep oscillations.

Alain Destexhe

In: Encyclopedia of Neuroscience, Edited by Squire LR, Academic Press, Oxford. Vol. 8, pp. 1037-1044 (2009).

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The thalamus and cerebral cortex are both implicated in the genesis of slow-wave sleep oscillations, such as sleep spindles or slow waves (up and down states). The activities of thalamic and cortical neurons during these oscillations have been well documented by electrophysiological studies. To determine the cellular mechanisms of sleep oscillations, it is necessary to use computational models tightly based on experimental data, as reviewed in this chapter. Different models successfully explained the genesis of sleep oscillations based on interactions between complex intrinsic neuronal properties and different synaptic receptor types present in cortical and thalamic circuits. These advances have raised interesting possibilities regarding the function of slow-wave sleep.
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