A new computational approach to estimate whole-brain effective
connectivity from functional and structural MRI, applied to language
Gerald Hahn, Michael A. Skeide, Dante Mantini, Marco Ganzetti,
Alain Destexhe, Angela D. Friederici, and Gustavo Deco.
Scientific Reports 9: 8479, 2019.
Recently introduced effective connectivity methods allow for the
in-vivo investigation of large-scale functional interactions between
brain regions. However, dynamic causal modeling, the most widely used
technique to date, typically captures only a few predefined regions of
interest. In this study, we present an alternative computational
approach to infer effective connectivity within the entire connectome
and show its performance on a developmental cohort with emerging
language capacities. The novel approach provides new opportunities to
quantify effective connectivity changes in the human brain.
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