Cellular correlates of wakefulness and slow-wave sleep:
evidence for a key role of inhibition.
Eduarda Susin and Alain Destexhe
Current Opinion Physiol. 15: 68-73, 2020.
Recent studies have identied interesting cellular dynamics in
wakefulness and slow-wave sleep (SWS), as we review here for unit
recordings in animals and human. First, a novel form of homeostasis
was observed during sleep, where high-firing cells in wake tend to
fire slower during SWS, while low-firing cells in wake tend to fire
faster in SWS. Second, there seems to be a stronger involvement of
inhibitory cells compared to excitatory cells during gamma
oscillations in SWS. Third, pairwise cross-correlations between
cells seem to increase specically during SWS, but only for
inhibitory neurons. We compare these results between animal and
human unit recordings, and confirm the similarities in cellular
dynamics in wake and SWS, and highlight that differences are mostly
apparent in the dynamics and correlations of inhibitory cells.
These results suggest that inhibitory networks are key in the
dynamics of sleep, and should be a main target in future studies.
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