Is the extracellular impedance high and non-resistive in cerebral cortex?

Claude Bedard and Alain Destexhe

Biophysical Journal 113: 1639-1642, 2017.

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A recent commentary to Biophysical Journal criticized a previous study published in the same journal by Gomes et al. in 2016, and an alternative interpretation of the measurements was proposed. We reply here to these criticisms and provide some additional clarification, in particular, about a possible misinterpretation of the electrical circuit corresponding to these experiments. We suggest that, indeed, the extracellular impedance in cerebral cortex could be high and non-resistive, and we propose further experiments to settle this issue.

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